About the Role

We are seeking an experienced and visionary Head of Chemistry to lead our small molecule strategy and drive innovation in mitochondrial biology. This is a senior leadership role at the forefront of therapeutic discovery, focused on developing novel compounds targeting mitochondrial dysfunction across a range of diseases.

You will play a critical role in shaping scientific direction, leading chemistry programmes from early discovery through preclinical development, and building a high-performing team in a fast-growing biotech environment.

Key Responsibilities

• Lead and oversee all chemistry activities, including medicinal chemistry, compound design, and optimisation
• Define and execute small molecule strategies targeting mitochondrial pathways
• Drive programmes from hit identification through lead optimisation and candidate selection
• Collaborate closely with biology, translational, and external partners to advance pipeline projects
• Build, mentor, and manage a high-performing chemistry team
• Establish and manage relationships with CROs and external collaborators
• Contribute to overall R&D strategy and represent chemistry at the leadership level
• Ensure delivery of high-quality data to support preclinical development and regulatory progression
• Stay at the forefront of advances in mitochondrial science and drug discovery technologies

Requirements

• PhD in Chemistry, Medicinal Chemistry, or related discipline
• Significant experience in small molecule drug discovery within biotech or pharma
• Proven track record of progressing compounds into preclinical or clinical development
• Strong background in medicinal chemistry and structure-based drug design
• Experience leading teams and managing cross-functional collaborations
• Knowledge or interest in mitochondrial biology or metabolic disease is highly desirable
• Strong leadership, communication, and strategic thinking skills

What We Offer

• Competitive executive-level salary and equity package
• Opportunity to shape the scientific direction of a cutting-edge biotech
• Collaborative, innovative, and mission-driven environment
• Flexible working and comprehensive benefits package

Summary

This is a unique opportunity to lead chemistry innovation in a high-impact area of biology, developing therapies that target mitochondrial dysfunction and address significant unmet medical needs.

Benefits

• Life insurance
• Income protection
• 5–10% employer contribution (common in biotech)
• 25–30 days holiday + bank holidays
• Often flexible/hybrid working
• Enhanced parental leave
• Learning & development budget
• Wellness perks